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Academic Curriculum Vitae

Wang Jian

AI for Protein Dynamics and Mechanical Modeling

Education

Ph.D. in Zhejiang University & Hong Kong Baptist University

Advisors: Wang Guannan, Tang Qianyuan

M.S. in Chang'an University

Major in Civil Engineering · Advisor: Ye Fei

B.E. in Chang'an University

Publications

  1. P1 Membrane Anisotropy Reshapes Scale-Free Correlations and Directional Mechanical Susceptibility in Transmembrane Proteins. Jian Wang; Zizheng He; Xiaoyi Chen; Guannan Wang; Qianyuan Tang. bioRxiv, 2026.
  2. P2 Cholesterol in Myelin: Supply Routes, Pathological Consequences, Biophysical Governance, and Future Frontiers. Xinyu Zhu; Fan Zhang; Jian Wang; Guannan Wang; Jiajia Wang. Neuroscience Bulletin, 2026.
  3. P3 Efficient modeling of Pile-Tunnel Interaction: A PINN-Based framework for vertical settlement prediction. Haoran Li; Fei Ye; Ruiqing Han; Jian Wang; Xingbo Han. Tunnelling and Underground Space Technology, 2026.
  4. P4 Fusing shield mechanical parameters to optimize tunneling quality: A case study of Chuning railway construction. Jian Wang; Biao He; Guannan Wang; et al. Engineering Applications of Artificial Intelligence (under review), 2025.
  5. P5 Multiscale Micromechanics Modeling of Viscoelastic Natural Plant Fibers. Jie Li; Jian Wang; Miao Wang; et al. Frontiers in Materials, 2024.
  6. P6 Effect of rolling angle on segment cracking and damage of shield tunnel - field investigation and modelling. Haolan Feng; Fei Ye; Yin Jiang; Jian Wang*; et al. Engineering Failure Analysis, 2022.
  7. P7 A kind of cutting and supporting dual-purpose mechanical equipment and method for disposing tunnel surrounding rock. Jian Wang; Li Chong; Li Peijun; et al. Invention CN111022094B, 2020.

Research Projects

Directional Mechanics and Functional Site Identification in Membrane Proteins

Developed an anisotropic elastic network model to resolve the directional mechanical specificity and scale-free fluctuations of transmembrane proteins governed by lipid membrane anisotropy. Formulated the Relative Directional Dynamic Flexibility Index to identify functional allosteric sites, capturing critical functional residues overlooked by isotropic DFI while preserving identification accuracy.

Mechanogating Dynamics Modeling of Piezo1 Ion Channels

Formulated a hybrid mechanics framework integrating coarse-grained elastic networks with vector-form intrinsic finite elements (VFIFE) to model structural proteins. Quantified the large-scale nonlinear gating and deformation transitions of Piezo1 under membrane tension, bypassing the temporal bottlenecks of conventional all-atom MD.

Multiscale Mechanical Modeling of Plant Fibers

Formulated a hierarchical multiscale framework integrating RVEs, the Mori-Tanaka scheme, and the viscoelastic correspondence principle to predict rate-dependent macroscopic behaviors.